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Synthesis of a tyrosine “homologue” of oxytocin

✍ Scribed by H. C. Beyerman; J. S. Bontekoe; A. C. Koch

Book ID
104586134
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
354 KB
Volume
79
Category
Article
ISSN
0165-0513

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✦ Synopsis

Abstract

A synthesis is described of the “protected” decapeptide N‐benzyloxycarbonyl‐S‐benzyl‐L‐cysteinyl‐L‐tyrosyl‐L‐tyrosyl‐L‐isoleucyl‐L‐glutaminyl‐L‐asparaginyl‐S‐benzyl‐L‐cysteinyl‐L‐prolyl‐L‐leucylglycineamide (V).

Removal of the blocking groups from V followed by oxidation yielded biologically active preparations believed to contain a “homologue” of oxytocin with two consecutive molecules of tyrosine instead of one (VI). Oxytocin‐inhibiting activities of VI have been described by other investigators.

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