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Synthesis of a tyrosine “homologue” of oxypressin

✍ Scribed by H. C. Beyerman; J. S. Bontekoe; A. C. Koch


Book ID
104586234
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
247 KB
Volume
79
Category
Article
ISSN
0165-0513

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✦ Synopsis


Abstract

The synthesis is described of the protected linear decapeptide: N‐benzyloxycarbonyl‐S‐benzyl‐L‐cysteinyl‐L‐tyrosyl‐L‐tyrosyl‐L‐phenylalanyl‐L‐glutaminyl‐L‐asparaginyl‐S‐benzyl‐L‐cysteinyl‐L‐prolyl‐L‐leucylglycineamide (III, Fig. 2).

Removal of the blocking groups from III, followed by oxidation, yielded a preparation assumed to contain a “homologue” of oxypressin with two consecutive molecules of tyrosine instead of one (Fig. 1, n = 2).


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## Abstract The synthesis is described of the protected linear decapeptide: __N__‐benzyloxycarbonyl‐__S__‐benzyl‐__L__‐cysteinyl‐__L__‐tyrosyl‐__L__‐tyrosyl‐__L__‐isoleucyl‐__L__‐glutaminyl‐__L__‐asparaginyl‐__S__‐benzyl‐__L__‐cysteinyl‐__L__‐prolyl‐__N__^e^‐tosyl‐__L__‐lysylglycineamide (II, Fig.