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Synthesis of a trans-chelating chiral diphosphine ligand with only planar chirality and its application to asymmetric hydrosilylation of ketones

✍ Scribed by Ryoichi Kuwano; Takashi Uemura; Makoto Saitoh; Yoshihiko Ito

Publisher: Elsevier Science
Year: 1999
Tongue: French
Weight: 238 KB
Volume: 40
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(98)02603-3

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✦ Synopsis

Optically active diphosphine (S,S)-2,2"-bis[(diethylphosphino)methyl]-1,1"-biferrocene (abbreviated to (S,S)-EtTRAP-H) was synthesized from ferrocenyloxazoline derived from L-valinol in 47% overall yield. The new chiral ligand, (S,S)-EtTRAP-H, which coordinates to a rhodium atom in a trans-ehelating manner, was effective for asymmetric hydrosilylation of ketones to give optically active secondary alcohols with up to 94% ee.

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