Synthesis of a taxinine analog via the intramolecular Diels-Alder cycloaddition
β Scribed by Jeffrey D. Winkler; Samit K. Bhattacharya; Robert A. Batey
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- French
- Weight
- 219 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0040-4039
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Oxidation of 20-hydroxy-4,5-ene-7-oxotaxinine 4 derived from a natural taxoid taxinine B via four steps gave a corresponding aldehyde 5, which afforded a new dimeric taxoid 6 through regio-and stereospecific hetero Diels-Alder cycloaddition. Similar hetero Diels-Alder reaction of 4:5,6:7-diene aldeh