𝔖 Bobbio Scriptorium
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Synthesis of a targeting drug for antifibrosis of liver; A conjugate for delivering glycyrrhetin to hepatic stellate cells

✍ Scribed by Jian Zhang; Qi-Sheng Zhang; Xiao-Ming Chen; Geng-Yuan Tian


Book ID
111583632
Publisher
Springer US
Year
2002
Tongue
English
Weight
134 KB
Volume
19
Category
Article
ISSN
1573-4986

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Synthesis of a Novel Pentagastrin-Drug C
✍ Lutzβ€…F. Tietze; Olaf Panknin; Felix Major; Birgit Krewer πŸ“‚ Article πŸ“… 2008 πŸ› John Wiley and Sons 🌐 English βš– 335 KB πŸ‘ 1 views

## Abstract The synthesis of the novel pentagastrin seco‐CBI conjugate **3**, which is based on the highly cytotoxic antitumor antibiotic (+)‐duocarmycin SA (**1**), is reported. A key step in the synthesis is the palladium‐catalyzed carbonylation of aryl bromide **7** to give the benzyl ester **16