Derivatization of the octadecathymidylate derivative 18 (T18 ODN) containing a free amine function with sulfo-SIAB@ gave the corresponding iodoacetyl ODN 21. Conjugation of the latter with the thiol-containing pentasaccharide 17c gave pentasaccharide-ODN conjugate 111, which exhibited anti-Xa and an
Synthesis of a spermidine-derived conjugating agent.
β Scribed by Christophe Morin; Michel Vidal
- Publisher
- Elsevier Science
- Year
- 1992
- Tongue
- French
- Weight
- 366 KB
- Volume
- 48
- Category
- Article
- ISSN
- 0040-4020
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β¦ Synopsis
a short synthesis of a spermidine conjugating agent is presented. Spermidine, 1, is implicated in diverse physiological processes that share as a common thread a close relationship to cell proliferation and growth; in particular, it associates with polyanions such as DNA and RNAs . Spermidine derivatives are usually accessible by way of multi-step elongation of lower homologues 1~ . The recent announcement
π SIMILAR VOLUMES
The synthesis and conversion era new spermidine equivalent (2) to squalamine is reported. It is prepared in a practical manner, is stable to sodium borohydride reduction, is converted to spermidine under mild conditions, and is not prone to internal cyclization reactions.