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Synthesis of a simplified analogue of eleutherobin via a Claisen rearrangement and ring closing metathesis strategy

โœ Scribed by Chiang, Gary C. H.; Bond, Andrew D.; Ayscough, Andrew; Pain, Gilles; Ducki, Sylvie; Holmes, Andrew B.


Book ID
120282924
Publisher
Royal Society of Chemistry
Year
2005
Tongue
English
Weight
111 KB
Volume
14
Category
Article
ISSN
1359-7345

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โœ Ok Hyun Ko; Joon Hee Hong ๐Ÿ“‚ Article ๐Ÿ“… 2002 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 72 KB

Very efficient synthetic route to novel 4%a-C-hydroxymethyl branched carbocyclic nucleosides was described. The stereocontrolled synthesis of target nucleosides was successfully achieved by Johnson orthoester-Claisen rearrangement, ring-closing metathesis (RCM) starting from a simple acyclic precurs