✦ LIBER ✦

Synthesis of a Radiotracer for Studying k-Subtype Opiate Receptors: N-[11C-methyl]-N-(trans-2-pyrrolidinyl-cyclohexyl)-3,4-dichlorophenylacetamide ([11C](±)U-50488H)

✍ Scribed by Glen D. Noble; Robert F. Dannals; Hayden T. Ravert; Alan A. Wilson; Henry N. Wagner Jr.

Book ID: 102901153
Publisher: John Wiley and Sons
Year: 1992
Tongue: French
Weight: 558 KB
Volume: 31
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580310202

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✦ Synopsis

Abstract

The radiochemical synthesis of a κ‐subtype opiate receptor ligand, ^11^CU‐50488H, was accomplished either in two steps or by direct methylation with [^11^C]iodomethane. The radiotracer was purified using reversed phase semipreparative HPLC. The average specific activity was 1830 mCi/μmole (calculated at the end‐of‐synthesis; EOS) for the direct methylation and 2140 mCi/μmole EOS for the two‐step one‐pot synthesis. The average time of synthesis including formulation was approximately 22 minutes for the direct methylation and 27 minutes for the two‐step one‐pot synthesis.

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Synthesis of a radiotracer for studying

Synthesis of a radiotracer for studying dopamine uptake sites in vivo using PET: 2β-carbomethoxy-3β-(4-fluorophenyl)-[N-11C-methyl]tropane ([11C]CFT or [11C]WIN-35,428)

✍ Robert F. Dannals; John L. Neumeyer; Richard A. Milius; Hayden T. Ravert; Alan A 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 French ⚖ 320 KB

## Abstract 2β‐Carbomethoxy‐3β‐(4‐fluorophenyl)‐[N‐^11^C‐methyl]tropane, a potent inhibitor of dopamine transport, was prepared by N‐methylation of the appropriate nor‐methyl precursor in DMF with [^11^C]iodomethane. After derivatization of unreacted precursor with a long chain acyl halide, the rad