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Synthesis of a pyrrolo annulated pyrido[2,3-D]pyrimidine as a potential nonclassical antifolate

✍ Scribed by Aleem Gangjee; Jasmin Patel; Fu-Tyan Lin


Book ID
112129090
Publisher
Journal of Heterocyclic Chemistry
Year
1988
Tongue
English
Weight
153 KB
Volume
25
Category
Article
ISSN
0022-152X

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Unusual dihydrazone formation in the fis
✍ Aleem Gangjee; Lihua Chen πŸ“‚ Article πŸ“… 1999 πŸ› Journal of Heterocyclic Chemistry 🌐 English βš– 323 KB

## Abstract The synthesis of seven novel tetracyclic 2,4‐diaminopyrrolo[2,3‐__d__]pyrimidines as conformationally restricted nonclassical antifolates was achieved __via__ an unusual Fischer‐indole cyclization of dihydrazones. An attempted synthesis of 2,4‐diamino‐6‐hydrazinopyrimidine afforded 2‐am