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Synthesis of a novel β-turn mimetic and its incorporation in Leu-enkephalin

✍ Scribed by Paul Kreye; Jan Kihlberg

Publisher: Elsevier Science
Year: 1999
Tongue: French
Weight: 223 KB
Volume: 40
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(99)01216-2

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✦ Synopsis

A conformationaily restricted 13-turn mimetic, in which an ethylene bridge replaces the intramolecular hydrogen bond between residues i and i + 3 of 13-turns, has been prepared and incorporated in Leu-enkephalin. Amino acids and a-bromoaeids were used as building blocks in the synthesis of the mimetic.

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