Synthesis of a novel pyrene-containing nucleoside and its incorporation into oligonucleotides

✍ Scribed by Jennifer D. Frazer; Stacy M. Horner; Stephen A. Woski

• Publisher: Elsevier Science
• Year: 1998
• Tongue: French
• Weight: 313 KB
• Volume: 39
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(97)10853-x

✦ Synopsis

The synthesis of the aryl nucleoside analogue P2'-deoxy-D-ribofuranosyl-l'-N-pyrenylcarboxamide (4) is described. This compound can be converted into a phosphoranudite reagent and used in solid phase oligonucleotide synthesis.