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ChemInform Abstract: Synthesis of a Novel Pyrene-Containing Nucleoside and Its Incorporation into Oligonucleotides.

✍ Scribed by J. D. FRAZER; S. M. HORNER; S. A. WOSKI

Publisher
John Wiley and Sons
Year
2010
Weight
28 KB
Volume
29
Category
Article
ISSN
0931-7597

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A High-Yield Synthesis of Deoxy-2-fluoroinosine and Its Incorporation into Oligonucleotides. -Diazotization of the deoxyguanosine derivative (I) followed by mild fluorination and selective O-silyl deprotection under the conditions shown provides an improved synthesis of the title nucleoside. It is