Synthesis of a Novel Prodrug of 3-(4′-Geranyloxy-3′-methoxyphenyl)-2-trans-propenoic Acid for Colon Delivery.
✍ Scribed by Massimo Curini; Francesco Epifano; Salvatore Genovese
- Publisher
- John Wiley and Sons
- Year
- 2006
- Weight
- 22 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0931-7597
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## Abstract Organotin(IV) complexes with general formula R~4 − __n__~SnL~__n__~ have been synthesized by the reaction of tri‐ and diorganotin chlorides with sodium salt of (__E__)‐3‐(4‐methoxyphenyl)‐2‐phenyl‐2‐propenoic acid in dry toluene, where RCH~3~, C~2~H~5~, __n__‐C~4~H~9~, C~6~H~5~, __n__
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Specifically labelled phenylacetic acid and mandelic acid derivatives, metabolites of L-Dopa, have been synthesized via the intermediary labelled benzyl alcohols, which were prepared by reduction of the methyl esters of the appropriate benzoic acids. The benzyl alcohols have been converted to the co