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Synthesis of a novel dimeric bis-benzimidazole with site-selective DNA-binding properties

✍ Scribed by Xiao-Wen Sun; Stephen Neidle; John Mann

Publisher: Elsevier Science
Year: 2002
Tongue: French
Weight: 66 KB
Volume: 43
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(02)01595-2

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✦ Synopsis

We describe the synthesis of bis(3-{4-[2%-(4-methoxyphenyl)-3H,3%H-[5,5%]bibenzimidazolyl-2-yl]phenoxy}propyl)methylamine 8, which has high affinity for the oligonucleotide sequence [A.T] 4 -[G.C]-[A.T] 4 .

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