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Rational Design, Synthesis, and DNA Binding Properties of Novel Sequence-Selective Peptidyl Congeners of Ametantrone

โœ Scribed by Alessandra Gianoncelli; Serena Basili; Matteo Scalabrin; Alice Sosic; Stefano Moro; Giuseppe Zagotto; Manlio Palumbo; Nohad Gresh; Barbara Gatto


Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
510 KB
Volume
5
Category
Article
ISSN
1860-7179

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## Abstract __Molecular modeling studies carried out with experimental DNA models with the sequence d[AG~3~(T~2~AG~3~)~3~] suggest that the introduction of a net positive charge onto the side chain of a series of fluorenone carboxamides can improve Gโ€quadruplex binding. The terminal morpholino moie