Synthesis of a non-peptide analogue of omega-conotoxin MVIIA
β Scribed by Stefan Menzler; Jack A Bikker; David C Horwell
- Book ID
- 104259960
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- French
- Weight
- 219 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0040-4039
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AbstractΓOmega-conotoxin MVIIA, a highly potent antagonist of the N-type voltage sensitive calcium channel, has shown utility in several models of pain and ischemia. We report a series of three alkylphenyl ether based analogues which mimic three key amino acids of the toxin. Two of the compounds hav
AbstractΓThree mimetics of the peptide v-Conotoxin MVIIA have been synthesised following the dendroid approach. The three key central amino acids of the natural peptide are mimicked by phenylguanidine (arginine), isopentyl (leucine) and aryl alcohol (tyrosine) attached to a quinolinone core at the 1