Synthesis of a new series of purine derivatives and their anti-cyclin-dependent kinase activities

✍ Scribed by Michel Legraverend; Odile Ludwig; Sophie Leclerc; Laurent Meijer

• Book ID: 102344346
• Publisher: Journal of Heterocyclic Chemistry
• Year: 2001
• Tongue: English
• Weight: 62 KB
• Volume: 38
• Category: Article
• ISSN: 0022-152X
• DOI: 10.1002/jhet.5570380145

✦ Synopsis

Abstract

The synthesis of new purine derivatives designed to inhibit cell cycle regulating cyclin‐dependent kinases (CDKs), is reported. These compounds, related to olomoucine and roscovitine, are characterised by the presence of apyrrolidine methanol substituent at C‐2 and a variety of ortho, meta and/or para substituents on the C‐6 arylamino group.