Synthesis of a new series of purine deri
β
Michel Legraverend; Odile Ludwig; Sophie Leclerc; Laurent Meijer
π
Article
π
2001
π
Journal of Heterocyclic Chemistry
π
English
β 62 KB
## Abstract The synthesis of new purine derivatives designed to inhibit cell cycle regulating cyclinβdependent kinases (CDKs), is reported. These compounds, related to olomoucine and roscovitine, are characterised by the presence of apyrrolidine methanol substituent at Cβ2 and a variety of __ortho,