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Cyclin-dependent kinase inhibitors: New compounds, selectivity, mechanisms of action and anti-proliferative activities

✍ Scribed by Laurent Meijer; Marie Knockaert


Book ID
117657912
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
170 KB
Volume
37
Category
Article
ISSN
0959-8049

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Synthesis of a new series of purine deri
✍ Michel Legraverend; Odile Ludwig; Sophie Leclerc; Laurent Meijer πŸ“‚ Article πŸ“… 2001 πŸ› Journal of Heterocyclic Chemistry 🌐 English βš– 62 KB

## Abstract The synthesis of new purine derivatives designed to inhibit cell cycle regulating cyclin‐dependent kinases (CDKs), is reported. These compounds, related to olomoucine and roscovitine, are characterised by the presence of apyrrolidine methanol substituent at C‐2 and a variety of __ortho,