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Synthesis of a new carbapenem with a 6-methyl hydroxyacetate side chain

✍ Scribed by Dieter Häbich; Wolfgang Hartwig

Publisher
Elsevier Science
Year
1987
Tongue
French
Weight
236 KB
Volume
28
Category
Article
ISSN
0040-4039

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An efficient synthesis of the side chain intermediate of BO-2502A, a new 1β-methyl carbapenem, via diastereoselective lactamization as a key step
✍ Norikazu Ohtake; Yasuyuki Imai; Ryosuke Ushijima 📂 Article 📅 1998 🏛 Elsevier Science 🌐 French ⚖ 555 KB

The BO-2502A side chain intermediate 3 was prepared via the diastereoselective lactamization of the in situ prepared amino diacid anhydride 14 as a key step. The diastereoselectivity of this step was found to be 53:1 (96% de).