Synthesis of a new bisdehydro analog of leukotriene A4
β Scribed by G. A. Tolstikov; M. S. Miftakhov; A. G. Tolstikov
- Book ID
- 112444482
- Publisher
- Springer
- Year
- 1983
- Tongue
- English
- Weight
- 46 KB
- Volume
- 32
- Category
- Article
- ISSN
- 1573-9171
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S-Y ## 2,2,3,3-[2H4]-l-Iodopentane (8b ) was prepared in four steps @m pmpargVr alcohol and used in the Calkylation of the THP-protected 3-butyne-1-01 (10). Subsequent protective p u p removal of Ilb, semideuteidon of the acetylenic alcohol 126, and further @ansformation by known methods afforded
The stereocontrolled synthesis of conformationally restricted LTD4 analogs 2a. b is described. Epoxidation of enone 4 affords a 2.4:1 mixture of trans-epoxide 5 and cis-epoxide 9. Stereocontrolled elaboration of each epoxide to final product involves stereoselective Wittig olefination to Z-olefins 6
A facile synthesis of LTA4 l\_ methyl ester was achieved according