๐”– Bobbio Scriptorium
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Synthesis of a Mexican bean beetle azamacrolide allomone via a novel lactam to lactone ring expansion

โœ Scribed by Gordon W. Gribble; Richard A. Silva


Book ID
103408965
Publisher
Elsevier Science
Year
1996
Tongue
French
Weight
186 KB
Volume
37
Category
Article
ISSN
0040-4039

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An enantioselective synthesis of the carbapenem antibiotic (+)-ps-5 is described. The starting point is the chiral Sharpless epoxyalcohol 2 which is transformed stereospecifically to the eziridine 6. Regioeelective ring-ope&ng of 6 by'LiEt Cu followed by RuQ oxidation yields the @-sulfonamide cat-bo