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Organocatalytic Ring Expansion of β-Lactams to γ-Lactams through a Novel N1−C4 Bond Cleavage. Direct Synthesis of Enantiopure Succinimide Derivatives

✍ Scribed by Alcaide, Benito; Almendros, Pedro; Cabrero, Gema; Ruiz, M. Pilar


Book ID
124057974
Publisher
American Chemical Society
Year
2005
Tongue
English
Weight
60 KB
Volume
7
Category
Article
ISSN
1523-7060

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N1–C4 β-Lactam Bond Cleavage in the 2-(T
✍ Benito Alcaide; Pedro Almendros; María C. Redondo 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 109 KB

## Abstract Starting substrates, enantiopure spiranic or 3‐substituted 3‐alkoxy‐4‐oxoazetidine‐2‐carbaldehydes, were prepared from (__R__)‐2,3‐__O__‐isopropylideneglyceraldehyde derived azetidine‐2,3‐diones by sequential Barbier‐type addition reactions followed by hydroxy functionalization and alde