𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthesis of a halogenated clavulone analog

✍ Scribed by Hiroto Nagaoka; Tohru Miyakoshi; Jun-ichi Kasuga; Yasuji Yamada

Book ID
104233293
Publisher
Elsevier Science
Year
1985
Tongue
French
Weight
226 KB
Volume
26
Category
Article
ISSN
0040-4039

No coin nor oath required. For personal study only.

✦ Synopsis

A halogenated clavulone analog 1 which has remarkable antitumor activity was synthesized in a stereoselective and enantioselective manner. We have described the structures of novel marine prostanoids clavulone I, II, III, IV and their congecers, which are noted by their strong antitumor activity, isolated from Japanese Stlonifer Clavularia viridis, 1 and also have reported an effective and enantioselective total synthesis of clavulones. 2 Recently chlorinated marine prostanoids punaglandins, whose structures are similar to those of clavulones, were isolated from Hawaiian octocoral by P.J.Scheuer et al., and the antitumor activities of these chlorinated prosta-

πŸ“œ SIMILAR VOLUMES

Total synthesis of clavulones
Total synthesis of clavulones
✍ Masakatsu Shibasaki; Yuji Ogawa πŸ“‚ Article πŸ“… 1985 πŸ› Elsevier Science 🌐 French βš– 238 KB
Total synthesis of (.+-.)-clavulones
Total synthesis of (.+-.)-clavulones
✍ Corey, E. J.; Mehrotra, Mukund M. πŸ“‚ Article πŸ“… 1984 πŸ› American Chemical Society 🌐 English βš– 163 KB
Synthesis and biological evaluation of C
Synthesis and biological evaluation of C-2 halogenated analogs of salvinorin A
✍ David Y.W. Lee; Lu Yang; Wei Xu; Gang Deng; Lin Guo; Lee-Yuan Liu-Chen πŸ“‚ Article πŸ“… 2010 πŸ› Elsevier Science 🌐 English βš– 358 KB

Salvinorin A (1), the main active ingredient of Salvia divinorum, is a potent and selective ΞΊ opioid receptor (KOPR) agonist. Based on the SAR, its C-2 position is one of the key binding sites and has very little space tolerance (3-4 carbons atoms) and limited to only lipophilic groups. In our attem