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Synthesis of a dendron and dendrimer consisting of MALDI matrix like branching units

✍ Scribed by Hendrik Neubert; Andrew T. Kicman; David A. Cowan; Sukhvinder S. Bansal

Book ID
104251847
Publisher
Elsevier Science
Year
2002
Tongue
French
Weight
159 KB
Volume
43
Category
Article
ISSN
0040-4039

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✦ Synopsis

The synthesis of a novel dendron and dendrimer with potential application in matrix-assisted laser desorption/ionization mass spectrometry (MALDI MS) is described. The dendrimer branching unit was designed to have structural similarities to cinnamic acid based matrices used in MALDI MS. Branching was incorporated into the structure by introducing a second acrylic acid side chain. Some intermediates of the monomer synthesis were shown to function as MALDI matrices. A second-generation dendron was assembled on a solid support employing an N-to-C directed convergent synthetic strategy. Coupling of the dendrons with a trivalent core molecule resulted in a second generation dendrimer.

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Synthesis of a chiral micelle-like dendr
Synthesis of a chiral micelle-like dendrimer with phenylene dendrons and a 1,1β€²-binaphthyl core
✍ Liu-Zhu Gong; Lin Pu πŸ“‚ Article πŸ“… 2001 πŸ› Elsevier Science 🌐 French βš– 251 KB

A novel chiral micelle-like dendrimer has been synthesized. This dendrimer contains a chiral binaphthyl core, meta-phenylene dendrons, and hydrophilic polyhydroxyl periphery groups. It is soluble in highly polar solvents such H 2 O/THF, MeOH/THF, EtOH/THF and DMSO, but insoluble in EtOAc, CH 2 Cl 2