Synthesis of a Conformationally Locked Version of Puromycin Amino Nucleoside
โ Scribed by Choi, Yongseok; George, Clifford; Strazewski, Peter; Marquez, Victor E.
- Book ID
- 118146148
- Publisher
- American Chemical Society
- Year
- 2002
- Tongue
- English
- Weight
- 52 KB
- Volume
- 4
- Category
- Article
- ISSN
- 1523-7060
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๐ SIMILAR VOLUMES
3'-Amino-3'-deoxythymidine was converted, in multi-steps, to its 5'-O-(4,4'-dimethoxytrityl)-5'-C-tosyloxyethyl-3'-N-carbobenzoxy derivative 7 and 5'-C-mesyloxyethyl-3'-N-(9-fluorenyl)methoxycarbonyl derivatives 6 and 11. Subsequent hydrogenolysis or treatment with DMAP afforded 3'-N,5'-C-bridged bi
## Abstract **Locked in translation**: Crucial insight into the ribosomal catalysis of peptideโbond formation is expected to be gained from the target compounds, which feature conformational locking in a __Northโ__type pucker, designed to interfere with the translation of the genetic code. The comp