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Synthesis of a chiral phosphonium salt for the preparation of α-substituted alaninol derivatives

✍ Scribed by Tsuji, Takashi; Suzuki, Keisuke; Nakamura, Tsuyoshi; Nishi, Takahide


Book ID
124136912
Publisher
Elsevier Science
Year
2014
Tongue
French
Weight
700 KB
Volume
70
Category
Article
ISSN
0040-4020

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On the use of PyAOP, a phosphonium salt
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Phosphonium derivatives of HOAt such as PyAOP are useful for the solid-phase preparation of a range of peptides that include those incorporating hindered amino acids, difficult short sequences, and cyclic peptides. An advantage relative to uronium salts is that excess PyAOP does not undergo the detr