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Synthesis of a chiral 1β-methylcarbapenem key intermediate using radical cyclization of N-vinylic α-bromo amides

✍ Scribed by Hiroyuki Ishibashi; Chisato Kameoka; Kazuya Kodama; Hirotaka Kawanami; Masahiro Hamada; Masazumi Ikeda

Publisher: Elsevier Science
Year: 1997
Tongue: French
Weight: 737 KB
Volume: 53
Category: Article
ISSN: 0040-4020
DOI: 10.1016/s0040-4020(97)00645-5

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✦ Synopsis

The chiral l~3-methylcarbapenem key intermediate 5 was synthesized by using radical cyclization of N-vinylic 0t-bromo amide 18 as a key step.

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