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ChemInform Abstract: Synthesis of a Chiral 1β-Methylcarbapenem Key Intermediate Using Radical Cyclization of N-Vinylic α-Bromo Amides.

✍ Scribed by H. ISHIBASHI; C. KAMEOKA; K. KODAMA; H. KAWANAMI; M. HAMADA; M. IKEDA


Publisher
John Wiley and Sons
Year
2010
Weight
34 KB
Volume
28
Category
Article
ISSN
0931-7597

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ChemInform Abstract: Total Synthesis of
✍ Masazumi Ikeda; Shinji Ohtani; Tatsunori Sato; Hiroyuki Ishibashi 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 35 KB 👁 1 views

Total Synthesis of (-)-γ-Lycorane Using Diastereoselective 5-endotrig Radical Cyclization of N-Vinylic α-Halo Amides. -Radical cyclization of the acetamides (IV) proceeds with only moderate diastereoselectivity. Major product (Va) is converted to the title alkaloid (XI). -