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Synthesis of a building block for phosphonate analogues of moenomycin A12 from d-tartaric acid

✍ Scribed by Jalal Zahra; Lothar Hennig; Matthias Findeisen; Peter Welzel; Dietrich Müller; William S Sheldrick

Publisher
Elsevier Science
Year
2001
Tongue
French
Weight
116 KB
Volume
42
Category
Article
ISSN
0040-4039

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✍ Kim F Albizati; Srinivasan Babu; Angela Birchler; Juliette K Busse; Michelle Fug 📂 Article 📅 2001 🏛 Elsevier Science 🌐 French ⚖ 80 KB

This letter describes a new synthesis of the HIV-protease inhibitor nelfinavir. The synthesis features a selective opening of a D-tartaric acid-derived cyclic sulfate with nitrogen nucleophiles.