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A synthesis of the HIV-protease inhibitor nelfinavir from d-tartaric acid

✍ Scribed by Kim F Albizati; Srinivasan Babu; Angela Birchler; Juliette K Busse; Michelle Fugett; Alan Grubbs; Aubrey Haddach; Miguel Pagan; Barbara Potts; Travis Remarchuk; Dale Rieger; Rick Rodriguez; Jim Shanley; Robert Szendroi; Tony Tibbetts; Kathleen Whitten; Bennett C Borer

Publisher: Elsevier Science
Year: 2001
Tongue: French
Weight: 80 KB
Volume: 42
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(01)01338-7

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✦ Synopsis

This letter describes a new synthesis of the HIV-protease inhibitor nelfinavir. The synthesis features a selective opening of a D-tartaric acid-derived cyclic sulfate with nitrogen nucleophiles.

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