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Synthesis of a bifunctional hapten designed to mimic both transition state and to induce “bait and switch” catalysis

✍ Scribed by Tingyu Li; Kim D. Janda


Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
182 KB
Volume
5
Category
Article
ISSN
0960-894X

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Haptens la and I b, transition-state analogs inducing phospholipase Az-like catalytic antibody, were synthesized. Hapten la inhibited hydrolysis of the sn-2 ester of phospholipid.