New synthesis of 5-amino-4-hydroxy-2,6-d
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Fabio Benedetti; Paolo Maman; Stefano Norbedo
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Article
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2000
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Elsevier Science
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French
⚖ 73 KB
Two stereoisomers of the title compound have been synthesized from the methyl ester of N-Boc L-valine. The aminoester was initially converted into an a%-amino a,b-unsaturated ketone via a phosphonoketone and a Horner-Emmons olefination with acetaldehyde. Hydrocyanation of the enone with diethylalumi