✦ LIBER ✦

A new enantioselective synthesis of (4S, 5S)-5-(N-Boc)-amino-6-cyclohexyl-4-hydroxy-hexanoic acid lactone, a hydroxyethylene dipeptide isostere precursor

✍ Scribed by Hiyoshizo Kotsuki; Aya Miyaki; Masamitsu Ochi

Publisher: Elsevier Science
Year: 1991
Tongue: French
Weight: 101 KB
Volume: 32
Category: Article
ISSN: 0040-4039
DOI: 10.1016/0040-4039(91)80024-z

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

The synthesis of (2S,4S,5S) -5-(N-BOC)-a

The synthesis of (2S,4S,5S) -5-(N-BOC)-amino-6-cyclohexyl-4-hydroxy-2-isopropyl-hexanoic acid lactone, an hydroxyethylene dipeptide isostere precusor

✍ Prasun K. Chakravarty; Stephen E. de Laszlo; Carol S. Sarnella; James P. Sprinng 📂 Article 📅 1989 🏛 Elsevier Science 🌐 French ⚖ 212 KB

A synthetic approach to the butyrolactones of (2SR,4SR)-S(S)-(N-Bo)-amino-6-cyclohexyl-4-hy~oxy-2-i~propyl hexanoic acid from

Synthesis of the hydroxyethylene dipepti

Synthesis of the hydroxyethylene dipeptide isostere, (2S,4S,5S)-5-amino-6-cyclohexyl-4-hydroxy-2-isopropyl hexanoic acid n-butyl amide

✍ Michael A. Poss; Joyce A. Reid 📂 Article 📅 1992 🏛 Elsevier Science 🌐 French ⚖ 249 KB

## A stereoselective synthesis of rhe hydroxyerhylene dipeptide isostere. ~2.~,4S.SP~-_~-(rmina-6 cyclQ~Kyl~4-hydrQxy-2-isQpropyl hawzoic acid n-bury1 amidffrom Bat-L-phenyinlmurw is described.

New synthesis of 5-amino-4-hydroxy-2,6-d

New synthesis of 5-amino-4-hydroxy-2,6-dimethylheptanoic acid, a hydroxyethylene isostere of the Val-Ala dipeptide

✍ Fabio Benedetti; Paolo Maman; Stefano Norbedo 📂 Article 📅 2000 🏛 Elsevier Science 🌐 French ⚖ 73 KB

Two stereoisomers of the title compound have been synthesized from the methyl ester of N-Boc L-valine. The aminoester was initially converted into an a%-amino a,b-unsaturated ketone via a phosphonoketone and a Horner-Emmons olefination with acetaldehyde. Hydrocyanation of the enone with diethylalumi

ChemInform Abstract: New Synthesis of 5-

ChemInform Abstract: New Synthesis of 5-Amino-4-hydroxy-2,6-dimethylheptanoic Acid, a Hydroxyethylene Isostere of the Val-Ala Dipeptide.

✍ Fabio Benedetti; Paolo Maman; Stefano Norbedo 📂 Article 📅 2001 🏛 John Wiley and Sons ⚖ 29 KB 👁 1 views

Stereoselective synthesis of N-Boc-O-ben

Stereoselective synthesis of N-Boc-O-benzyl-(4S,5S)-5-amino-4-hydroxy-6-phenylhexanoic acid, the hydroxyethylene isosteric moiety of potent HIV-1 protease inhibitor

✍ Tk Chakraborty; Kiran Kumar Gangakhedkar 📂 Article 📅 1991 🏛 Elsevier Science 🌐 French ⚖ 152 KB

N-Boc-O-benzyl-(4S,5S)-5-amino-4-hydroxy-6-phenylhexanoic acid is synthesized in a highly stereoselective way involving, as a key step, regioselective opening of carbohydrate-based aziridine ring.