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Synthesis of a [3H]-labelled derivative of the microtubular poison taxol

✍ Scribed by J. Chenu; M. Takoudju; M. Wright; V. Senilh; D. Guénard

Publisher
John Wiley and Sons
Year
1987
Tongue
French
Weight
365 KB
Volume
24
Category
Article
ISSN
0022-2135

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✦ Synopsis

A labelled derivative of the microtubule poison tazol ha8 been developed on acetylation of the ?-OH function of tml o i t h ['HI acetic anhydride. The [*HI 7-acetyl taxot synthesized was chemicatZy and radiochemically pure and has not undergone radiOty8iS cluring 2.5 years. This compound W Q ~ also stable in the presence of microtubule proteins. Ths I D of 7-acetyl tmi! f o r stabilization of microtubules %s two times the IDso o f taxot. Hence it can be used as a probe for biologzcat studies. The acetylation of the hydrowl group a t position C-7 is a general method applicable t o other tax01 derivatives as starting compounds.

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