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Synthesis of 99mTc-labeled organo-germanium nanoparticles and their in vivo study as a spleen imaging agent

✍ Scribed by Sang Hyun Park; Hui Jeong Gwon; Junhwa Shin

Publisher
John Wiley and Sons
Year
2006
Tongue
French
Weight
167 KB
Volume
49
Category
Article
ISSN
0022-2135

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✦ Synopsis

99m Tc-Labeled organo-germanium nanoparticles ranging in size from 60 to 80 nm were newly developed for a spleen imaging agent. The radiolabeled nanoparticles were prepared with a high labeling efficiency (over 99%) and they also showed an excellent stability at room temperature for 6 h. The biodistribution data of the nanoparticles injected into rats via intravenous routes showed a notably higher accumulation in the spleen when compared to other reticuloendothelial system organs. Gamma image of the rabbits obtained after an intravenous injection of the nanoparticles revealed a localization of the radioactivity mainly in the spleen and the liver.

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