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Synthesis of 8-Phenoxy-2′-deoxyguanosine Nucleoside Analogues

✍ Scribed by Heidi A. Dahlmann; Shana J. Sturla

Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
263 KB
Volume
2011
Category
Article
ISSN
1434-193X

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## Abstract 8‐[^18^O]Hydroxy‐2′‐deoxyguanosine was synthesized starting from 8‐bromo‐2′‐deoxyguanosine and the sodium salt of [^18^O]benzyl alcohol, resulting in the intermediate 8‐[^18^O]benzyloxy‐2′‐deoxyguanosine. Subsequent reduction by catalytic transfer hydrogenation, yielded the desired prod