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Oligonucleotide Incorporation of 8-Thio-2′-deoxyguanosine.

✍ Scribed by Michelle L. Hamm; Rushina Cholera; Courtney L. Hoey; Timothy J. Gill

Publisher
John Wiley and Sons
Year
2005
Weight
55 KB
Volume
36
Category
Article
ISSN
0931-7597

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## Abstract 8‐[^18^O]Hydroxy‐2′‐deoxyguanosine was synthesized starting from 8‐bromo‐2′‐deoxyguanosine and the sodium salt of [^18^O]benzyl alcohol, resulting in the intermediate 8‐[^18^O]benzyloxy‐2′‐deoxyguanosine. Subsequent reduction by catalytic transfer hydrogenation, yielded the desired prod