Syn thes is of 14C -labe 1 led 4 -chloro -3 -s u l f amoyl -N -(3aa, 4a, 5 , 6 7a,7aa-hexahydro-4,7-methano-isoindolin-Z-yl)-benzamide.
Synthesis of 7α-chloro-16α-methylprednisolone 17α,21-dipropionate-4-14c (alclometasone dipropionate-4-14c)
✍ Scribed by Tadao Terasawa; Kazunori Atsumi; Tetsuyoshi Yokoshima; Shintaro Ohyabu; Noboru Fukasaku
- Publisher
- John Wiley and Sons
- Year
- 1986
- Tongue
- French
- Weight
- 475 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0022-2135
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## Abstract ^14^C‐Labelled __N__‐(2‐chloro‐3,4‐dimethoxybenzylideneamino)guanidinium acetate has been synthesized as a part of a four‐step procedure which involved decarboxylation of 2‐chloro‐3,4‐dimethoxybenzoic acid by Pb(OAc)~4~ to give 2‐chloro‐3,4‐dimethoxy‐1‐iodobenzene, followed by a selecti
## Abstract The title compound 9 was prepared by the route outlined in Scheme I. [^14^C]Thiourea (1) was condensed with ethyl 4‐bromo‐3‐oxo‐2‐methoxyiminoacetate (2), providing ethyl 2‐(2‐amino‐4‐[2‐^14^C]thiazolyl)‐2‐methoxyiminoacetate (3), as the pure Z‐isomer. Saponification gave the amino acid
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