Synthesis of 7.alpha.-methoxycephalosporins
โ Scribed by Applegate, H. E.; Dolfini, J. E.; Puar, M. S.; Slusarchyk, W. A.; Toeplitz, B.; Gougoutas, J. Z.
- Book ID
- 125930557
- Publisher
- American Chemical Society
- Year
- 1974
- Tongue
- English
- Weight
- 396 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0022-3263
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๐ SIMILAR VOLUMES
Recently much effort has been directed towards the synthesis of 7-methoxycephalosporins because of the finding of the cephamycin group and their enhanced activity towards gram negative bacteria1'2'3). We also have studied and reported 4) some novel reactions for introducing a methoxy group at C7 po
Sodium 7~-Cyanomethylthioacetamido-7a-14C-methoxy- 3-[ (1-methyl-1H-tetrazol-5-yl) thiomethyl) -3-cephem-4-carboxylate (CS-1170), a new cephamycin derivative was prepared for metabolic studies, The key reaction involves the methoxylation o f t'he diphenylmethyl 7-( 3 , 4 -d i -~-b u t y l -4 -o x 0