𝔖 Bobbio Scriptorium
✦   LIBER   ✦

A synthesis of 7-methoxycephalosporin and its novel rearrangement

✍ Scribed by Yukio Sugimura; Yuji Iwano; Kimio Iino; Tokio Saito; Tetsuo Hiraoka

Book ID
104235420
Publisher
Elsevier Science
Year
1977
Tongue
French
Weight
238 KB
Volume
18
Category
Article
ISSN
0040-4039

No coin nor oath required. For personal study only.

✦ Synopsis

Recently much effort has been directed towards the synthesis of 7-methoxycephalosporins because of the finding of the cephamycin group and their enhanced activity towards gram negative bacteria1'2'3).

We also have studied and reported 4) some novel reactions for introducing a methoxy group at C7 position of cephalosporins. Now we wish to report a modified C7-methoxylation and a novel rearrangement of the resulting 7-methoxycephalosporin derivative.

7~-(3-Phenyl-2,3-dibromopropionyl)amino-3-methyl-3-cephem-4-carboxylic acid methyl ester (la) was converted to the corresponding imino chloride with PC15-quinoline in chloroform, and -

📜 SIMILAR VOLUMES

Synthesis of 14C-labeled 7α-methoxycepha
Synthesis of 14C-labeled 7α-methoxycephalosporin derivative (14C-cefotetan)
✍ Kazuharu Tamazawa; Hideki Arima 📂 Article 📅 1982 🏛 John Wiley and Sons 🌐 French ⚖ 295 KB 👁 1 views

## Abstract [Caboxamido‐^14^C]Cefotetan, 7α‐[4‐(carbamoyl carboxymethylene)‐1,3‐dithietan‐2‐yl] [^14^C]carboxamido‐7α‐methoxy‐3‐(1‐methyl‐1H‐tetrazol‐5‐yl)thiomethyl‐y1)thiomethyl‐3‐cephem‐4‐carboxylic acid (IX), a new cephamycin derivative, was synthesized from bromo[1‐^14^C]acetic acid for metabo

Synthesis of 14C-labelled 7α-methoxyceph
Synthesis of 14C-labelled 7α-methoxycephalosporin derivative (CS-1170)
✍ Hideo Nakao; Koichi Fujimoto; Hiroaki Yanagisawa 📂 Article 📅 1978 🏛 John Wiley and Sons 🌐 French ⚖ 225 KB

Sodium 7~-Cyanomethylthioacetamido-7a-14C-methoxy- 3-[ (1-methyl-1H-tetrazol-5-yl) thiomethyl) -3-cephem-4-carboxylate (CS-1170), a new cephamycin derivative was prepared for metabolic studies, The key reaction involves the methoxylation o f t'he diphenylmethyl 7-( 3 , 4 -d i -~-b u t y l -4 -o x 0