𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthesis of 7-benzoxazol-2-yl and 7-benzothiazol-2-yl-6-fluoroquinolones

✍ Scribed by Thomas O. Richardson; Vinayak P. Shanbhag; Kimberly Adair; Shantel Smith

Book ID
102340321
Publisher
Journal of Heterocyclic Chemistry
Year
1998
Tongue
English
Weight
315 KB
Volume
35
Category
Article
ISSN
0022-152X

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The fluoroquinolones, 7‐benzoxazol‐2‐yl‐1‐ethyl‐6‐fluoro‐1,4‐dihydro‐4‐oxoquinoline‐3‐carboxylic acid and 7‐benzothiazol‐2‐yl‐1‐ethyl‐6‐fluoro‐1,4‐dihydro‐4‐oxoquinoline‐3‐carboxylic acid, were synthesized. The compounds were obtained by use of the Gould‐Jacobs route to the quinoline ring system. The required anilines, 3‐benzoxazol‐2‐yl‐4‐fluorophenylamine and 3‐benzothiazol‐2‐yl‐4‐fluorophenylamine were obtained by the cyclodehydration reaction of 5‐amino‐2‐fluorobenzoic acid with 2‐aminophenol or 2‐aminothiophenol respectively using polyphosphoric acid.

📜 SIMILAR VOLUMES

3-(Benzoxazol-2-yl)-7-hydroxy­chromen-2-
3-(Benzoxazol-2-yl)-7-hydroxy­chromen-2-one methanol solvate
✍ Franca, Eduardo de Faria ;Machado, Antonio Eduardo da Hora ;Oliveira-Campos, Ana 📂 Article 📅 2003 🏛 International Union of Crystallography 🌐 English ⚖ 248 KB

Single-crystal X-ray study T = 120 K Mean '(C±C) = 0.003 A Ê R factor = 0.048 wR factor = 0.121 Data-to-parameter ratio = 9.3 For details of how these key indicators were automatically derived from the article, see http://journals.iucr.org/e.