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Synthesis of 7- and 5,7-substituted-6-fluoro-2-methyl-1,2,3,4-tetrahydroquinolines: Convenient precursors of quinolone antibacterial agents

✍ Scribed by Pascal Bouyssou; Corinne Le Goff; Jacques Chenault


Book ID
112130367
Publisher
Journal of Heterocyclic Chemistry
Year
1992
Tongue
English
Weight
324 KB
Volume
29
Category
Article
ISSN
0022-152X

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## Abstract Condensation of 2‐hydroxyacetophenone with benzaldehyde in the presence of 70% perchloric acid in ethyl orthoformate gave the corresponding 4‐ethoxyflavylium perchlorate, which was treated with aqueous ammonia or methylamine solution to afford 1,6,7,8‐substituted 2‐(3β€²,4′‐substituted‐ph