Synthesis of 6α-[18F]Fluoroprogesterone: A first step towards a potential receptor-ligand for PET
✍ Scribed by Tjibbe J. de Groot; Anton H. Braker; Philip H. Elsinga; Gerben M. Visser; Willem Vaalburg
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 318 KB
- Volume
- 45
- Category
- Article
- ISSN
- 0969-8043
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract The __α__~2~‐adrenergic receptor antagonist atipamezole has been labelled with carbon‐11 using [^11^C]formaldehyde and 2‐ethyl‐2‐oxoacetylindane. Various routes are proposed for the synthesis of the latter: oxidation of 2‐acetyl‐2‐ethylindane, hydrolysis of 2‐diethoxy‐2‐indane and oxida
Nicotinic acetylcholine receptors are widely distributed throughout the human brain and are believed to play a role in several neurological and psychiatric disorders. In order to identify an effective PET radioligand for in vivo assessment of the a4b2 subtype of nicotinic receptor, we synthesized [
~F]-1-(3-Fluoropropyl)-4-(4-cyanophenoxymethyl)piperidine has been prepared as a potential sigma-I receptor ligand for PET. The unlabeled ligand was found to be selective in vitro for the sigma-I receptor [Ki(crl) = 4.3 nM] when tested in a variety of neuroreceptor binding assays. Furthermore, the l
## Abstract In psychiatric disorders such as anxiety, depression and schizophrenia, 5‐HT~2A~ receptors play an important role. In order to investigate them __in vivo__ there is an increasing interest in selective and high‐affinity radioligands for receptor binding studies using positron emission to
## Abstract In an attempt to visualize the NMDA glutamatergic receptors and after checking the biological activity of the cold 3‐fluoromethyl‐TCP 3, 3‐[^18^F]‐fluoro‐methyl‐TCP 4 was synthesized by a nucleophilic substitution of 3‐bromomethyl‐TCP 5 with [^18^F^−^].