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Synthesis of 6(S)-amino-7-cyclohexyl-4,4-difluoro-3(R),5(R)-dihydroxy-2-methyiheptane, a novel dipeptide mimic

✍ Scribed by Sham, Hing L.; Rempel, Cheryl A.; Stein, Herman; Cohen, Jerome


Book ID
120268060
Publisher
The Royal Society of Chemistry
Year
1990
Tongue
English
Weight
158 KB
Volume
13
Category
Article
ISSN
0022-4936

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A Practical Synthesis of the Dihydroxyet
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The N-Boc dihydroxyethylene dipeptide isostere 7 and its N-Boc 3-(thiazol-4-ylJalany1 derivative 8 were synthesized, without purification of intermediates, from (4S~R)-22-dimethyl-4-(2-methy~propylJ-5-hydro~~thyl-l.3-dioxolane (361, in 24 and 32% overall yield, respectively, Alcohol 38 was readily p