A diastereoselective synthesis of (2S, 3R, 4S)-2-amino-1-cyclohexyl-6-methylheptane-3,4-diol, the Abbott aminodiol
β Scribed by Christopher W. Alexander; Dennis C. Liotta
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- French
- Weight
- 210 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0040-4039
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π SIMILAR VOLUMES
The N-Boc dihydroxyethylene dipeptide isostere 7 and its N-Boc 3-(thiazol-4-ylJalany1 derivative 8 were synthesized, without purification of intermediates, from (4S~R)-22-dimethyl-4-(2-methy~propylJ-5-hydro~~thyl-l.3-dioxolane (361, in 24 and 32% overall yield, respectively, Alcohol 38 was readily p
The tide compounds were prepared from key intermediates readily obtained by the stereoselective Diels-Alder reaction of (Z)-2-pbenyl-4-[(S)-2,2-dimethyl-l,3dioxolan-4-ylmethylene]-5(4H)-oxazolone, a chiral az-lactone derived from (R)glyceraldehyde and cyclopentadiene.
## Synthesis and transformations of (1R,2R,3S,4R)-4-O- benzylhydroxylamino-2,3-O-isopropylidene-1,2,3-cyclopentanetrioh synthesis of (1S,2R,3S,4R)-4-amino-2,3-O-isopropylidene-l,2,3cyclopentanetriol