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Synthesis of 6-Substituted 9-Benzyl-8-hydroxypurines with Potential Interferon-Inducing Activity.

✍ Scribed by Kazunori Kazaoka; Hironao Sajiki; Kosaku Hirota

Publisher
John Wiley and Sons
Year
2003
Weight
135 KB
Volume
34
Category
Article
ISSN
0931-7597

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✦ Synopsis

Abstract

For Abstract see ChemInform Abstract in Full Text.

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## Abstract Alkylation of 6,7‐difluoro‐4‐hydroxyquinoline‐3‐carboxylic acid ethyl ester with substituted‐benzyl chlorides gave 1‐(substituted‐benzyl)‐6,7‐difluoro‐1,4‐dihydro‐4‐oxoquinoline‐3‐carboxylic acid ethyl esters. Their treatment with piperazine or __N__‐methylpiperazine in pyridine yielded