𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthesis and Anti-HIV-1 Activity of New MKC-442 Analogues with an Alkynyl-Substituted 6-Benzyl Group*

✍ Scribed by Youssef L. Aly; Erik B. Pedersen; Paolo La Colla; Roberta Loddo


Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
714 KB
Volume
340
Category
Article
ISSN
0365-6233

No coin nor oath required. For personal study only.


📜 SIMILAR VOLUMES


Synthesis and Anti-HIV-1 Evaluation of N
✍ Krzysztof Danel; Per T. Jørgensen; Erik B. Pedersen; Paolo La Colla; Gabriella C 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 German ⚖ 289 KB

## Abstract The MKC‐442 analogue 6‐(3,5‐dimethylbenzyl)‐5‐ethyluracil substituted with a (propargyloxo)methyl group at N(1) has previously been found highly active against HIV‐1. The CC bond in the substituent at N(1) is here utilized in a series of chemical reactions in order to develop new agent

Synthesis and anti-HIV-1 activity of 1,3
✍ Youssef L. Aly; Erik B. Pedersen; Paolo La Colla; Roberta Loddo 📂 Article 📅 2007 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 447 KB 👁 1 views

## Abstract magnified image Reaction of 1,3‐phenylenediacetonitrile with the zinc organometallic reagent of ethyl 2‐bromobutyrate afforded the 1,3‐phenylene‐bis(acetoacetate) **2** which was used as the starting material for the synthesis of 1,3‐phenylene‐bis[6‐(2‐thiouracil)] **4**. Desulphurizat

Synthesis and Anti-HIV-1 Activity of New
✍ Yasser M. Loksha; Erik B. Pedersen; Roberta Loddo; Paolo La Colla 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 167 KB 👁 2 views

## Abstract Coupling of 6‐benzyl‐5‐hydroxymethyluracil (**1**) with formaldehyde acetals followed by fluorination using (diethylamino)sulfur trifluoride (DAST) afforded 1‐alkenyloxymethyl and 1‐propargyloxymethyl 5‐fluoromethyl‐6‐benzyluracils **3a–c**. 6‐(3,5‐Dimethylbenzyl)‐5‐ethyl‐1‐[(2‐fluoroet