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ChemInform Abstract: Synthesis and anti-HIV-1 Activity of New Fluoro-HEPT Analogues: An Investigation on Fluoro versus Hydroxy Substituents.

✍ Scribed by Yasser M. Loksha; Erik B. Pedersen; Roberta Loddo; Paolo La Colla


Publisher
John Wiley and Sons
Year
2011
Weight
45 KB
Volume
42
Category
Article
ISSN
0931-7597

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Synthesis and Anti-HIV-1 Activity of New
✍ Yasser M. Loksha; Erik B. Pedersen; Roberta Loddo; Paolo La Colla 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 167 KB 👁 2 views

## Abstract Coupling of 6‐benzyl‐5‐hydroxymethyluracil (**1**) with formaldehyde acetals followed by fluorination using (diethylamino)sulfur trifluoride (DAST) afforded 1‐alkenyloxymethyl and 1‐propargyloxymethyl 5‐fluoromethyl‐6‐benzyluracils **3a–c**. 6‐(3,5‐Dimethylbenzyl)‐5‐ethyl‐1‐[(2‐fluoroet