Synthesis and Anti-HIV-1 Activity of New
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Yasser M. Loksha; Erik B. Pedersen; Roberta Loddo; Paolo La Colla
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Article
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2011
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John Wiley and Sons
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English
⚖ 167 KB
👁 2 views
## Abstract Coupling of 6‐benzyl‐5‐hydroxymethyluracil (**1**) with formaldehyde acetals followed by fluorination using (diethylamino)sulfur trifluoride (DAST) afforded 1‐alkenyloxymethyl and 1‐propargyloxymethyl 5‐fluoromethyl‐6‐benzyluracils **3a–c**. 6‐(3,5‐Dimethylbenzyl)‐5‐ethyl‐1‐[(2‐fluoroet