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Synthesis of 6-Substituted 2(1H)-Pyridon-3-yl C-2′-Deoxyribonucleosides

✍ Scribed by Hubert Chapuis; Tomáš Kubelka; Nicolas Joubert; Radek Pohl; Michal Hocek


Book ID
112082707
Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
628 KB
Volume
2012
Category
Article
ISSN
1434-193X

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Synthesis of 6-Substituted 1-Deazapurine
✍ Thomas Wenzel; Frank Seela 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 German ⚖ 590 KB

## Abstract The synthesis of 6‐substituted 1‐deazapurine 2′‐deoxyribonucleosides is described. Glycosylation of the 1‐deazapurine (imidazo[4,5‐__b__]pyridine) anions with the α‐D‐halogenose 5 gives stereoselectively __N__^7^‐ and __N__^9^‐ regioisomers. ^1^H‐NMR NOE and ^13^C‐NMR spectroscopy are u