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Synthesis of 6-phosphonoalkyl tetrahydro-4-pyrimidine-carboxylic acids as NMDA receptor antagonists

✍ Scribed by Christopher F. Bigge; Jiang-Ping Wu; James R. Drummond

Book ID: 103399076
Publisher: Elsevier Science
Year: 1991
Tongue: French
Weight: 193 KB
Volume: 32
Category: Article
ISSN: 0040-4039
DOI: 10.1016/0040-4039(91)80558-n

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## Abstract magnified image The Bigenelli acid catalyzed condensation of 2‐pyridylcarboxaldehyde (**1**), urea (**2**) and an alkyl acetoacetate (**3**) afforded the respective alkyl (Me, Et, __i__‐Pr, __i__‐Bu, __t__‐Bu) 6‐methyl‐4‐(2‐pyridyl)‐1,2,3,4‐tetrahydro‐2__H__‐pyrimidine‐2‐one‐5‐carboxyl